GLP-1 Semaglutide
CAS 910463-68-2 · Single GLP-1R agonist
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| Compound | Semaglutide (NN9535) |
|---|---|
| CAS Number | 910463-68-2 |
| Class | GLP-1 receptor agonist — single agonist |
| Structure | 31-AA analog of human GLP-1(7-37); Aib at position 8 (DPP-4 resistance); C18 fatty diacid at Lys26 via OEG/γ-Glu linker |
| Molecular Weight | 4113.58 Da |
| Form | Lyophilized powder, sealed vial |
| Purity | ≥99% by HPLC-MS; identity confirmed by MS |
| Half-Life | ~7 days (albumin binding) |
| Storage | −20 °C lyophilized; 2–8 °C after reconstitution |
| Solubility | Sterile / bacteriostatic water |
| Shelf Life | 24 months unopened, protected from light & moisture |
Research Areas
Studied in GLP-1R pharmacology (receptor binding, cAMP signaling), obesity and T2DM preclinical models (DIO mouse/rat; STEP-trial reference data), cardiovascular outcome models, hypothalamic appetite-pathway research, and mono-vs-multi agonist comparative pharmacology.