GLP-3 Retatrutide
LY3437943 · CAS 2381089-83-2 · Triple agonist
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| Compound | Retatrutide (GLP-3R, LY3437943) |
|---|---|
| CAS Number | 2381089-83-2 |
| Class | Triple receptor agonist — GLP-1, GIP, and glucagon receptors |
| Structure | 39-AA synthetic peptide with C18 fatty-acid modification |
| Molecular Formula | C₂₂₁H₃₄₂N₄₆O₆₈ |
| Molecular Weight | 4731.33 Da |
| Form | Lyophilized powder, sealed vial |
| Purity | ≥99% by HPLC; identity confirmed by MS |
| Half-Life | ~6 days (albumin binding) |
| Storage | −20 °C lyophilized; 2–8 °C after reconstitution |
| Status | Investigational compound — no approved formulation; Phase 3 TRIUMPH program ongoing |
Research Areas
A key reagent for multi-receptor metabolic research: receptor-binding dynamics across GLP-1R/GIPR/GCGR, hepatic lipid-oxidation and thermogenesis models, energy-expenditure studies, and comparative mono/dual/triple agonist pharmacology. Published Phase 2 data (NEJM 2023, Jastreboff et al.) serve as reference literature.